Triptorelin

Triptorelin Peptide

Triptorelin is a synthetic, highly effective decapeptide analog of the hypothalamic hormone, gonadotropin-releasing hormone (GnRH), also known as luteinizing hormone-releasing hormone (LHRH). This compound is structurally optimized to ensure maximum receptor affinity and significantly prolonged metabolic stability relative to the native peptide. Triptorelin functions as a potent agonist at the GnRH receptors located on the anterior pituitary gonadotroph cells. This initial binding rapidly stimulates the release of pituitary hormones, namely luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Crucially, its mechanism involves a shift upon continuous exposure, leading to sustained receptor desensitization and widespread downregulation. This well-documented biphasic action results in the powerful and lasting suppression of gonadotropin release. Triptorelin is consequently an invaluable research compound for exploring the mechanisms underlying pituitary hormone regulation, the complex dynamics of the hypothalamic–pituitary–gonadal (HPG) axis, and specialized research in reproductive endocrinology and tumor biology.

Triptorelin Peptide - 2mg Overview

Triptorelin is a structurally enhanced synthetic GnRH analog engineered for superior stability and pharmacological activity. Its molecular structure incorporates two key substitutions: the replacement of the natural residue at position 6 with the highly stable stereoisomer D-tryptophan, and the substitution of the C-terminal glycine with an ethylamide group. These targeted chemical modifications are essential, as they provide robust resistance to enzymatic degradation and dramatically optimize binding efficiency and half-life at the GnRH receptor site.

Research confirms that Triptorelin demonstrates greater intrinsic potency and a considerably extended duration of action compared to the native GnRH and legacy synthetic analogs like Buserelin. This compound is extensively used in experimental endocrinology for precise investigations into the feedback mechanisms and suppressive effects on the HPG axis. Moreover, its reliable ability to suppress sex hormone production makes it a vital tool in research models focusing on puberty modulation, the biochemistry of fertility control, and therapeutic approaches in hormone-dependent tumor models.

Triptorelin Peptide Structure

Triptorelin is a decapeptide with the molecular formula C64H82N18O13 and a molecular weight of 1311.45 grams/mol. Its structural fidelity ensures predictable and potent biological effects.

The full primary amino acid sequence (structure solution formula) is described as:

pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH-C2H5

Triptorelin Peptide Research

Triptorelin serves as a sophisticated research agent, providing controlled manipulation of the endocrine system's key regulatory pathways.

Pituitary and Gonadal Axis Regulation

Triptorelin's unique interaction with GnRH receptors facilitates detailed study of pituitary function. The immediate, transient stimulation is swiftly followed by prolonged receptor desensitization and downregulation. This mechanism creates a reliable, research-grade model of reversible hypogonadotropic hypogonadism, which is crucial for investigating systemic feedback loops and the impact of controlled hormonal withdrawal on target tissues.

Reproductive and Fertility Research

In reproductive studies, Triptorelin is used to modulate the hormonal environment. Pulsatile administration protocols are employed to accurately simulate the natural, cyclical GnRH release required for normal ovulation and spermatogenesis. In contrast, continuous administration establishes a powerful research model of reproductive inhibition, enabling researchers to isolate and study sex steroid-dependent processes under conditions of profound gonadotropin suppression.

Endocrine and Tumor Biology

The compound's capacity to induce functional suppression of gonadal steroids is highly relevant for cancer research. Triptorelin is a staple in experimental models of androgen-dependent prostate cancer and estrogen-dependent breast cancer. These studies aim to advance the understanding of hormone deprivation pathways and their integral role in tumor regression, providing crucial data for the development of new endocrine therapies.

Pubertal and Neuroendocrine Studies

In developmental neuroendocrinology, Triptorelin is a key reference compound used to investigate the complex timing and control of pubertal onset. It is utilized to map the activity of the hypothalamic GnRH pulse generator, assess changes in pituitary receptor sensitivity across development, and explore the molecular processes of receptor desensitization in neuroendocrine communication.

Pharmacokinetics

Triptorelin's structural enhancements result in a significantly higher GnRH receptor binding affinity and a markedly slower plasma clearance rate compared to native GnRH. These combined pharmacokinetic attributes ensure a sustained, potent biological effect, making it highly reliable for chronic experimental protocols demanding consistent, long-term hormonal suppression.

Research Peptide Summary

This product is strictly manufactured and supplied exclusively for non-clinical, in-vitro laboratory research. It is not approved or intended for human consumption, veterinary use, or therapeutic/diagnostic purposes.

Feature

Description

Peptide Name

Triptorelin

Peptide Classification

GnRH (LHRH) Decapeptide Analog

Purity Assurance

High Purity (>98%) confirmed via HPLC

Reconstitution Protocol

Requires Bacteriostatic Water (BW)

Primary Endocrine Effect

GnRH Agonism followed by Receptor Downregulation/Suppression

Research Applications

HPG Axis, Hormone-Sensitive Tumor Models, Reproductive Control

Molecular Formula

C64H82N18O13

Molecular Weight

1311.45 g/mol

Supplied State

Lyophilized Powder

Storage and Handling Instructions

Adherence to these storage and handling guidelines is crucial for maintaining the Triptorelin peptide's structural integrity and biological activity, ensuring the accuracy and reproducibility of all laboratory results.

General Storage Instructions

• Lyophilized Stability: Triptorelin is provided as a highly stable lyophilized (freeze-dried) powder, robust for transit and short-term ambient conditions.
• Short-Term Storage: For immediate use or storage up to a few months, the lyophilized peptide must be kept refrigerated at temperatures below 4 degrees C (39 degrees F) in a sealed, light-protected container.
• Long-Term Storage: For extended preservation over multiple months to years, the lyophilized powder should be stored frozen at -20 degrees C or -80 degrees C (-112 degrees F). Freezing is the most reliable method for long-term stability.

Best Practices for Handling

• Aliquoting: To prevent the structural damage caused by repeated freeze-thaw cycles, the peptide should be divided into smaller, single-use aliquots immediately upon receipt, before being placed into long-term frozen storage.
• Moisture Prevention: Triptorelin is hygroscopic. Always allow the sealed vial to warm completely to room temperature before opening to prevent condensation from contaminating the powder.
• Air Exposure: The time the vial is open to the atmosphere must be minimized. Promptly and securely reseal the container after dispensing.
• Freezer Warning: Do not use frost-free freezers for long-term storage, as their automatic temperature cycles accelerate peptide degradation.

Storing Peptides in Solution

Peptides stored in liquid solution are inherently less stable and more susceptible to degradation than the lyophilized powder.

• Reconstitution: Once reconstituted (typically using bacteriostatic water), the solution must be stored refrigerated at 4 degrees C (39 degrees F), where its stability is typically limited to 30 days.
• Sensitive Residues: Peptides containing easily oxidizable residues like Cysteine (C), Methionine (M), or Tryptophan (W) require minimal liquid storage time and should be handled with extra care.

Peptide Storage Containers

Appropriate storage vessels are essential for maintaining purity.

• Material: High-quality glass vials are recommended for their superior chemical inertness and are preferred for long-term storage.